The Evolution of the WHI 80+ Cohort

Area of Science:

• Gerontology
• Epidemiology
• Women's Health

Background:

• The Women's Health Initiative (WHI) has gathered extensive data on postmenopausal women for over 20 years.
• A significant number of WHI participants have reached 80 years or older, forming a valuable 80+ cohort.
• Previous research has not specifically characterized this 80+ cohort or identified factors influencing their continued participation.

Purpose of the Study:

• To characterize the demographic and health-related factors associated with retention in the Women's Health Initiative's 80+ cohort.
• To identify predictors of study retention among women aged 80 and older.
• To describe longitudinal health changes within this aging cohort.

Main Methods:

• Analysis of baseline data from the Women's Health Initiative for participants who would be at least 80 years old by September 17, 2012.
• Summarization of retention rates during initial data collection and two re-enrollment campaigns.
• Statistical analysis to identify demographic and health characteristics predicting retention and to describe longitudinal changes.

Main Results:

• Retention rates were higher during initial data collection (90%) compared to re-enrollment periods (74% and 83%).
• Women retained in the 80+ cohort were more likely to be white, educated, and healthier at baseline.
• Despite decreased physical activity and increased cardiovascular disease, women aged 80+ experienced modest changes in body mass index and depression.

Conclusions:

• The characteristics of retained women in the 80+ cohort differ significantly from their baseline profiles.
• Understanding attrition factors in older cohorts is crucial, as aging and health decline negatively impact participation.
• Targeted strategies are needed to enhance retention rates among older adults, particularly those with poorer health outcomes.