Related Experiment Video
Updated: Apr 13, 2026
07:09
Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
Published on: January 7, 2019
8.1K
Molecular Pathogenesis of MALT Lymphoma
Katharina Troppan1, Kerstin Wenzl1, Peter Neumeister1
1Division of Hematology, Department of Internal Medicine, Medical University of Graz (MUG), 8036 Graz, Austria.
Gastroenterology Research and Practice
|April 30, 2015
Summary
Extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) involves genetic aberrations and chronic infections. Oncogenic products cooperate with immune stimulation for malignant transformation.
Area of Science:
- Oncology
- Immunology
- Genetics
Background:
- Extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) accounts for approximately 8% of non-Hodgkin lymphomas.
- MALT lymphomas commonly occur in extranodal sites like the stomach, lung, ocular adnexa, and thyroid.
Purpose of the Study:
- To review the genetic aberrations in MALT lymphoma.
- To discuss the association between MALT lymphoma and chronic infections.
- To summarize recent advances in the molecular pathogenesis of MALT lymphoma.
Main Methods:
- Literature review of genetic abnormalities in MALT lymphoma.
- Analysis of the role of NF-κB signaling pathway genes.
- Examination of the interplay between genetic alterations and immunological stimulation.
Main Results:
- Specific chromosomal translocations and mutations in NF-κB pathway genes are implicated in MALT lymphoma development.
- Genetic abnormalities alone are insufficient for malignant transformation.
- Oncogenic products cooperate with chronic bacterial infections or autoimmune processes.
Conclusions:
- MALT lymphoma pathogenesis involves a complex interplay of genetic aberrations and immunological stimulation.
- Chronic infections and autoimmune processes are significant co-factors in MALT lymphoma development.
- Understanding molecular pathogenesis is crucial for targeted therapies.
Related Concept Videos
02:23Abnormal Proliferation
5.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K
01:31Antigen Processing Pathways
3.1K
MHC molecules are key players in the immune response, enabling T cells to recognize and respond to specific antigens. They are present on the surface of all nucleated cells in the body and are instrumental in presenting antigens to T cells and activating them. T cells recognize the MHC-antigen complex and initiate an immune response. MHC class I and MHC class II are two main types of MHC molecules, each associated with a distinct antigen processing pathway.
MHC Class I: Presenting Endogenous...
MHC Class I: Presenting Endogenous...
3.1K
01:31The Intrinsic Apoptotic Pathway
9.3K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
9.3K
01:15Secondary Lymphoid Organs
10.5K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
10.5K