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Potential of Mesenchymal Stem Cell based application in Cancer

Sushilkumar Ramdasi1, Shabari Sarang1, Chandra Viswanathan1

  • 1Regenerative Medicine Group, Reliance Life Sciences Pvt. Ltd. Dhirubhai Ambani Life Sciences Centre, R-282, TTC Area of MIDC, Thane-Belapur Road, Rabale, Navi Mumbai - 400701. India.

International Journal of Hematology-Oncology and Stem Cell Research
|April 30, 2015
PubMed

Insights

Mesenchymal stem cells (MSCs) show anti-tumor potential, migrating to tumors and potentially delivering therapeutic agents. Their role in cancer is complex, but they may induce cancer cell death via TRAIL.

Area of Science:

  • Oncology
  • Stem Cell Biology
  • Immunology

Background:

  • Mesenchymal stem cells (MSCs) are investigated for cancer treatment due to their tumor-homing ability and immune-privileged nature.
  • MSCs can exhibit both pro-tumorigenic and anti-tumorigenic effects within the tumor microenvironment, influenced by various factors.
  • Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) secreted by MSCs shows potential for inducing cancer cell apoptosis.

Purpose of the Study:

  • To review the dual role of MSCs in cancer, examining both their tumor-promoting and tumor-suppressing properties.
  • To explore the potential of MSCs, particularly those derived from umbilical cord tissue, in delivering anti-cancer therapies.
  • To investigate the expression of TRAIL by MSCs in co-culture systems and its effect on cancer cell apoptosis.

Main Methods:

  • Review of existing literature on MSCs and their interactions with various cancer cell lines.
  • Analysis of studies investigating MSCs' tumor tropism and therapeutic agent delivery capabilities.
  • Examination of research on MSC-secreted factors, focusing on TRAIL's role in apoptosis induction.

Main Results:

  • MSCs possess properties advantageous for cancer therapy, including tumor site migration and potential for differentiation.
  • The influence of MSCs on cancer progression is context-dependent, varying with MSC source, cancer type, and microenvironmental factors.
  • Studies suggest that MSCs can upregulate TRAIL expression, leading to apoptosis in co-cultured cancer cells, particularly those derived from umbilical cord tissue.

Conclusions:

  • MSCs present a promising platform for cancer treatment, with their anti-tumorigenic functions being a key area of research.
  • Further investigation into umbilical cord tissue-derived MSCs and their TRAIL expression is warranted for therapeutic development.
  • Understanding the complex interplay between MSCs and the tumor microenvironment is crucial for optimizing their anti-cancer potential.
Keywords:
Anti-cancerCancerMesenchymal Stem CellsTropismTumor

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