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Experimental Generation of Carcinoma-Associated Fibroblasts CAFs from Human Mammary Fibroblasts

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Published on: October 25, 2011

The growing fibroadenoma.

Linda M Sanders¹, Rana Sara²

¹Breast Center, Ambulatory Care Center, Barnabas Health, Livingston, NJ, USA ; Department of Radiology, Rutgers University, Newark, NJ, USA.

Acta Radiologica Open

|April 30, 2015

Summary

Malignancy within fibroadenomas (FAs) diagnosed by core biopsy is rare. Growing FAs also show a very low risk of cancer, suggesting routine follow-up may not be necessary for benign diagnoses.

Keywords:

Fibroadenoma (FA)Phyllodes tumors (PT)breast neoplasms breast ultrasound core biopsy mammography

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Area of Science:

Breast pathology
Oncology
Radiology

Background:

Fibroadenomas (FAs) are common breast tumors in young women.
Core biopsy is increasingly used for FA diagnosis, necessitating imaging follow-up.
Management guidelines for growing FAs require re-evaluation.

Purpose of the Study:

To determine the incidence of epithelial abnormalities in FAs diagnosed by core biopsy.
To assess the risk of malignancy in enlarging FAs.
To re-evaluate the management of growing FAs.

Main Methods:

Retrospective review of 2062 nodular FAs diagnosed over 19 years.
Identification of 83 FAs that enlarged after initial core biopsy.
Analysis of subsequent management and pathology for enlarging FAs.

Main Results:

Malignancy (atypia, in situ, or invasive) was found in 0.58% of initial core biopsies.
None of the 83 enlarging FAs showed malignancy; two were benign phyllodes tumors.
The incidence of cancer in growing FAs was 0% in this series.

Conclusions:

Malignancy adjacent to or within core-biopsied FAs is rare.
The risk of cancer in growing FAs is negligible, questioning the need for specific follow-up.
Excision is recommended for FAs with abnormal epithelial findings; otherwise, routine follow-up is likely unnecessary.