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Current antiplatelet treatment strategy in patients with diabetes mellitus

Jung Hwa Jung1, Udaya S Tantry2, Paul A Gurbel2

  • 1Division of Endocrinology, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Korea.

Diabetes & Metabolism Journal
|April 30, 2015
PubMed

Insights

Patients with diabetes mellitus (DM) experience heightened platelet reactivity, increasing cardiovascular risks. This review explores challenges and strategies for optimizing antiplatelet therapy in diabetic patients to prevent atherothrombotic events.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Endocrinology

Background:

  • Diabetes mellitus (DM) accelerates atherosclerosis, elevating risks of atherothrombotic cardiovascular events.
  • Diabetic patients exhibit high platelet reactivity, hypercoagulability, and reduced response to standard antiplatelet drugs.
  • These factors contribute to a higher incidence of adverse cardiovascular outcomes in individuals with DM.

Purpose of the Study:

  • To review current knowledge on platelet abnormalities in patients with diabetes mellitus.
  • To discuss the challenges and future perspectives of antiplatelet treatment strategies for this population.

Main Methods:

  • Literature review of studies on platelet function and antiplatelet therapy in diabetes.
  • Analysis of current antithrombotic treatment strategies, including dose modification, potent agents, and triple therapy.
  • Focus on the interplay between diabetes, platelet activation, and cardiovascular complications.

Main Results:

  • Patients with DM present with distinct platelet abnormalities, including increased reactivity and activation.
  • Standard antiplatelet therapies may be less effective in diabetic individuals, necessitating tailored approaches.
  • Various strategies, such as adjusted dosing, potent agents, and triple therapy, are being explored to manage the prothrombotic state.

Conclusions:

  • Understanding platelet dysfunction in DM is crucial for effective cardiovascular risk management.
  • Optimizing antiplatelet strategies is essential to mitigate the increased risk of atherothrombotic events in diabetic patients.
  • Further research is needed to refine and personalize antiplatelet therapies for individuals with diabetes.

Keywords:
AspirinAtherothrombosisDiabetesP2Y12 inhibitorPlatelet

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