Related Experiment Video
Updated: Apr 13, 2026
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Parecoxib reduces renal injury in an ischemia/reperfusion model in rats
José Pedro Calistro Neto1, Rômulo da Costa Torres1, Giovanna Maria Gonçalves2
1UNESP, Brazil.
Purpose:
To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model.
Methods:
Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, heart rate, body temperature, NGAL levels, and renal histology were compared across groups.
Results:
The Ischemia (I) group, which did not receive parecoxib, showed the highest NGAL levels (p=0.001), while the IP group, which received the medication, had NGAL levels similar to those of the non-ischemic (NI and NIP) groups.
Conclusion:
Parecoxib resulted in renal protection in this experimental model.
