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Related Experiment Video

Updated: Apr 13, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

Aerobic Exercise Promotes a Decrease in Right Ventricle Apoptotic Proteins in Experimental Cor Pulmonale.

Rafael Colombo¹, Rafaela Siqueira, Adriana Conzatti

¹Laboratory of Cardiovascular Physiology and Reactive Oxygen Species, Physiology Department, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.

Journal of Cardiovascular Pharmacology

|April 30, 2015

Summary

Exercise training reduced harmful hydrogen peroxide signaling in the right ventricle (RV) of rats with pulmonary arterial hypertension. This intervention mitigated apoptosis, suggesting a beneficial effect for Cor pulmonale treatment.

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Area of Science:

Cardiovascular Physiology
Exercise Science
Molecular Biology

Background:

Pulmonary arterial hypertension (PAH) leads to Cor pulmonale, characterized by right ventricular (RV) dysfunction.
Hydrogen peroxide (H2O2) signaling plays a role in RV remodeling in PAH.

Purpose of the Study:

To investigate the impact of exercise training on H2O2-dependent signaling pathways in the RV of rats with experimentally induced Cor pulmonale.

Main Methods:

Rats were induced with monocrotaline to model Cor pulmonale and subjected to a 5-week exercise training protocol.
Pulmonary artery pressure, RV hypertrophy, and molecular markers of apoptosis (Bax/Bcl-2, caspase 3) and signaling (p-Akt) were assessed.

Main Results:

Monocrotaline-induced rats showed increased pulmonary resistance, pressure, and RV hypertrophy.
Elevated H2O2 levels and apoptotic markers were observed in sedentary monocrotaline rats.
Exercise training significantly reduced H2O2 levels, decreased apoptotic signaling, and increased p-Akt in the RV.

Conclusions:

Exercise training exerts a protective effect against Cor pulmonale progression in rats.
The benefits of exercise involve the downregulation of H2O2 and subsequent reduction in RV apoptosis.