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Related Concept Videos

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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This lesson discusses the stability of substituted cyclohexanes with a focus on energies of various conformers and the effect of 1,3-diaxial interactions.
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Related Experiment Video

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A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
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Core-shell polymeric microcapsules with superior thermal and solvent stability.

Sen Kang1, Marta Baginska2, Scott R White2

  • 1†Beckman Institute for Advanced Science and Technology, Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.

ACS Applied Materials & Interfaces
|April 30, 2015
PubMed
Summary
This summary is machine-generated.

Polydopamine (PDA) coatings protect core-shell microcapsules from harsh conditions. This enhanced stability preserves capsule integrity and core content in extreme temperatures and solvents.

Keywords:
microcapsulespolydopaminesolvent stabilitythermal stability

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Core-shell microcapsules are susceptible to degradation in challenging environments.
  • Developing robust protective coatings is essential for microcapsule applications.

Purpose of the Study:

  • To investigate the efficacy of polydopamine (PDA) as a protective coating for core-shell microcapsules.
  • To determine the optimal conditions for PDA coating application.

Main Methods:

  • Core-shell microcapsules were coated with PDA via dopamine monomer polymerization.
  • A neutral aqueous solution and ammonium persulfate oxidant were employed.
  • Coating thickness and stability were characterized under various conditions.

Main Results:

  • A dense, uniform PDA layer approximately 50 nm thick was successfully applied.
  • PDA-coated microcapsules exhibited significantly enhanced stability at 180 °C.
  • Coated microcapsules retained integrity in organic solvents and acidic/basic solutions, unlike uncoated ones.

Conclusions:

  • Polydopamine coating provides robust protection to core-shell microcapsules.
  • PDA-coated microcapsules demonstrate superior stability in extreme thermal and chemical environments.
  • This method offers a viable strategy for improving microcapsule durability for diverse applications.