Related Experiment Video
Updated: Apr 13, 2026
Assessment of Maternal Vascular Remodeling During Pregnancy in the Mouse Uterus
Published on: December 5, 2015
Longitudinal cerebrovascular reactivity during pregnancy: a case study
Craig D Steinback1, Emily C King, Margie H Davenport
1Program for Pregnancy and Postpartum Health, Faculty of Physical Education and Recreation, University of Alberta, Edmonton, AB T6G 2E1, Canada., Physical Activity and Diabetes Lab, Faculty of Physical Education and Recreation, University of Alberta, Edmonton, AB T6G 2H9, Canada.
Normal cerebrovascular adaptation during pregnancy is poorly understood. We document a case study of progressively increased cerebrovascular reactivity to CO2, despite no change in resting blood flow, from prepregnancy to late gestation in a 36-year-old normotensive participant. Increased cerebral reactivity was related to progressive chronic respiratory alkalosis and specifically elevated pH and reduced HCO3(-). These novel data serve as important indicators of normative maternal cerebral adaptation and highlight novel areas of future study.
Normal cerebrovascular adaptation during pregnancy is poorly understood. We document a case study of progressively increased cerebrovascular reactivity to CO2, despite no change in resting blood flow, from prepregnancy to late gestation in a 36-year-old normotensive participant. Increased cerebral reactivity was related to progressive chronic respiratory alkalosis and specifically elevated pH and reduced HCO3(-). These novel data serve as important indicators of normative maternal cerebral adaptation and highlight novel areas of future study.
