Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Teratogenicity01:07

Teratogenicity

4.6K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.6K
Karyotyping01:17

Karyotyping

70.5K
Overview
70.5K
Karyotyping01:17

Karyotyping

12.1K
12.1K
Meiosis vs. Mitosis02:57

Meiosis vs. Mitosis

75.0K
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
75.0K
Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

684
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
684
Genomic Imprinting and Inheritance02:30

Genomic Imprinting and Inheritance

39.0K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
39.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinicopathological phenotypes of singleton stillbirth: A retrospective cohort study.

Acta obstetricia et gynecologica Scandinavica·2026
Same author

The role of placental anastomoses in severe brain injury after fetal demise in monochorionic twins: a multicenter retrospective study.

American journal of obstetrics and gynecology·2026
Same author

The genomic medicine center Karolinska 10-year report on genome sequencing for rare diseases and a strategy for stepwise clinical implementation.

Genome medicine·2026
Same author

Stillbirth in Iceland 1996-2021: Incidence and etiology.

Acta obstetricia et gynecologica Scandinavica·2025
Same author

Diagnostic yield of 1000 trio analyses with exome and genome sequencing in a clinical setting.

Frontiers in genetics·2025
Same author

Genome sequencing in a cohort of 32 fetuses with genetic skeletal disorders.

European journal of human genetics : EJHG·2025

Related Experiment Video

Updated: Apr 13, 2026

Murine Fetal Echocardiography
08:04

Murine Fetal Echocardiography

Published on: February 15, 2013

18.3K

Fetal calcifications are associated with chromosomal abnormalities.

Ellika Sahlin1, Meeli Sirotkina2, Andreas Marnerides2

  • 1Department of Molecular Medicine and Surgery and Center for Molecular Medicine, Karolinska Institutet, CMM L8:02, Karolinska University Hospital, S-171 76, Stockholm, Sweden.

Plos One
|April 30, 2015
PubMed
Summary

Fetal tissue calcifications are linked to a higher risk of chromosomal abnormalities, especially when combined with malformations. Identifying calcifications alongside malformations significantly increases the likelihood of detecting chromosomal issues in newborns.

More Related Videos

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System
07:34

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

Published on: May 5, 2018

12.5K
Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
09:03

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

10.0K

Related Experiment Videos

Last Updated: Apr 13, 2026

Murine Fetal Echocardiography
08:04

Murine Fetal Echocardiography

Published on: February 15, 2013

18.3K
Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System
07:34

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

Published on: May 5, 2018

12.5K
Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
09:03

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

10.0K

Area of Science:

  • Perinatal Pathology
  • Fetal Development
  • Medical Genetics

Background:

  • Fetal tissue calcifications, often found in the liver, have an unclear biological significance.
  • Previous studies suggest associations with infection, circulatory issues, malformations, or chromosomal abnormalities.
  • This study investigates factors associated with fetal calcifications in a large cohort.

Purpose of the Study:

  • To identify factors associated with fetal calcifications.
  • To determine the relationship between fetal calcifications, malformations, and chromosomal abnormalities.
  • To assess the diagnostic value of calcifications in predicting chromosomal abnormalities.

Main Methods:

  • A case-control study involving 151 fetuses with calcifications and 302 matched controls.
  • Chromosome analysis using karyotyping or quantitative fluorescence-polymerase chain reaction.
  • Review of autopsy and placenta reports for malformations and infection signs.

Main Results:

  • Calcifications were primarily in the liver, but also in other organs.
  • Fetuses with calcifications had a significantly higher rate of chromosomal abnormalities (50% vs. 20%).
  • Common abnormalities included trisomy 21, trisomy 18, and monosomy X; calcifications with malformations increased chromosomal abnormality detection probability.

Conclusions:

  • Fetal calcifications are associated with an increased risk of chromosomal abnormalities, particularly when co-occurring with malformations.
  • Identifying fetal calcifications alongside malformations significantly raises the probability of detecting chromosomal abnormalities.
  • Fetal calcifications, detected via autopsy or ultrasound, warrant careful evaluation for co-existing malformations as indicators of chromosomal abnormalities.