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Updated: Apr 13, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
[Temperament traits associated with bipolar affective disorder: an integrative literature review]
Alina Gomide Vasconcelos1, Leandro Fernandes Malloy-Diniz2, Elizabeth do Nascimento3
1Programa de Pós-Graduação em Neurociências, Universidade Federal de Minas Gerais, Belo Horizonte, MG.
Abstract:
Studies have suggested an association between temperament characteristics and adjustment and psychiatric disorders, describing them as different manifestations of vulnerability to psychopathology. The objective of this study was to conduct an integrative review of the literature on temperament traits typical of bipolar patients in relation to the general population. A systematic search was conducted on the MEDLINE, PsycINFO and LILACS databases, using the headings bipolar disorder, temperament and/or personality, between January 2000 and December 2010. The search was performed in January 2011. A total of 199 articles were identified for potential inclusion in the review. After application of the exclusion criteria, a total of 15 articles were selected and their full texts analyzed. Review of the selected studies revealed heterogeneity in terms of sample profile and specific temperament traits assessed with the appropriate instruments. Temperament traits in bipolar patients are identified based on different theoretical models. The results of five studies consistently showed that neuroticism is a distinct personality trait in the temperament profile of bipolar patients. Future reviews should use more specific keywords and limit the search to studies with a longitudinal design.
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