Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

NEP89: universal neuroevolution potential for inorganic and organic materials across 89 elements.

Nature computational science·2026
Same author

Seconds-scale exfoliation of high-quality 2D crystals enabled by polycyclic aromatic hydrocarbon radical anion-mediated organoalkali intercalation.

Nature communications·2026
Same author

Enhancing Whole Slide Image Classification in Renal Cell Carcinoma via Swin Transformer-Based Multiple Instance Learning.

Bioengineering (Basel, Switzerland)·2026
Same author

Characterization of sexually acquired HIV-1 transmission networks and genetic variation in northern frontier China, 2021-2024.

Frontiers in public health·2026
Same author

What do cancer patients discuss online regarding CINV management? A social media-based topic modeling study.

Frontiers in oncology·2026
Same author

Vactosertib reverses ABCG2-mediated multidrug resistance through dual inhibition of drug efflux and transporter expression.

Experimental cell research·2026

Related Experiment Video

Updated: Apr 13, 2026

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

2.1K

Light-triggered, self-immolative nucleic Acid-drug nanostructures.

Xuyu Tan1, Ben B Li2,3, Xueguang Lu1

  • 1†Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States.

Journal of the American Chemical Society
|April 30, 2015
PubMed
Summary

Researchers developed a novel nucleic acid-drug nanostructure for simultaneous intracellular delivery. This self-deliverable system releases drugs and nucleic acids upon light activation, simplifying complex delivery methods.

More Related Videos

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

4.8K
DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

12.3K

Related Experiment Videos

Last Updated: Apr 13, 2026

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

2.1K
Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

4.8K
DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

12.3K

Area of Science:

  • Biotechnology
  • Nanomedicine
  • Drug Delivery

Background:

  • Simultaneous intracellular delivery of diverse payloads like hydrophobic drugs and nucleic acids often necessitates intricate carrier systems.
  • Existing methods for co-delivery face challenges in complexity and efficiency.

Purpose of the Study:

  • To engineer a self-deliverable nucleic acid-drug nanostructure composed primarily of payload molecules.
  • To demonstrate light-activated, sequential release of nucleic acids and drugs from the nanostructure.
  • To evaluate the stability and therapeutic efficacy of the released payloads.

Main Methods:

  • Fabrication of a nanostructure comprising a nucleic acid shell and a prodrug core.
  • Light-activated dissociation of the nucleic acid shell.
  • Irreversible self-immolative disintegration of the prodrug core to release free drug molecules.
  • Assessment of nanostructure stability against DNase I.
  • In vitro evaluation of released drug efficacy against cancer cells.

Main Results:

  • The nanostructure demonstrated self-deliverability, simplifying simultaneous payload delivery.
  • Light activation triggered the release of the nucleic acid shell and subsequent disintegration of the prodrug core.
  • The nanostructures exhibited superior stability against DNase I compared to free DNA.
  • The released camptothecin showed comparable anti-cancer efficacy to free, unmodified camptothecin.

Conclusions:

  • A novel, payload-centric nanostructure enables efficient, light-triggered co-delivery of nucleic acids and drugs.
  • This approach offers enhanced stability and maintains therapeutic efficacy, presenting a simplified alternative to complex delivery systems.
  • The developed nanostructure holds promise for advanced therapeutic applications in cancer treatment.