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Updated: Apr 13, 2026

Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis

Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis

Published on: October 17, 2016

Fiber probe for nonlinear imaging applications.

Aleksandar Lukić^1,2, Sebastian Dochow^1,2, Olga Chernavskaia^1,2

¹Friedrich-Schiller University of Jena, Institute of Physical Chemistry and Abbe Center of Photonics, Helmholtzweg 4, 07743, Jena, Germany.

Journal of Biophotonics

|April 30, 2015

Summary

This summary is machine-generated.

A novel fiber optic probe enables in-vivo coherent anti-Stokes Raman scattering (CARS) endoscopy. This advancement allows for tissue diagnosis and tumor identification in hard-to-reach areas without external scanning mechanisms.

Keywords:

diagnostic imaging fiber optic technology microscopy multimodal imaging

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Area of Science:

Biomedical Optics
Medical Imaging
Fiber Optics

Background:

Multimodal imaging combining CARS, TPEF, and SHG shows promise for tissue diagnosis and tumor identification.
Current limitations exist for in-vivo screening in difficult-to-access body regions due to probe requirements.

Purpose of the Study:

To develop a fiber optic probe for in-vivo CARS imaging.
To extend the applicability of multimodal imaging for endoscopic tissue screening.

Main Methods:

Development of a novel CARS imaging fiber probe with 10,000 coherent light-guiding elements.
Preservation of spatial relationship between fiber entrance and output.
Shifting the scanning procedure to the proximal end of the fiber probe.

Main Results:

The novel fiber probe enables in-vivo CARS endoscopy.
No moving parts or driving current are required for operation.
Facilitates tissue diagnosis and tumor identification in challenging anatomical locations.

Conclusions:

The developed CARS imaging fiber probe is suitable for in-vivo endoscopic applications.
This technology advances the potential for minimally invasive tissue diagnosis.
Overcomes limitations of current multimodal imaging for internal body region screening.