Proniosomes in transdermal drug delivery
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Updated: Apr 13, 2026

Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
Published on: September 26, 2025
Yahya Rahimpour, Maryam Kouhsoltani, Hamed Hamishehkar1
1Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. hamishehkarh@tbzmed.ac.ir.
Abstract:
Proniosomes are liquid crystalline-compact niosomal hybrid that can be hydrated to form niosomal dispersion instantly before use. It is a promising drug carrier with better physical and chemical stability than niosomes. Proniosomes have the potential to be scaled up for industrial purposes. They have been remarkably considered for transdermal drug delivery because of their competences, including the penetration enhancing ability of surfactants and their non-toxic characteristics. This review offers current approaches in the research and development of proniosomal formulations for the transdermal delivery of drugs with a focus on therapeutic applications.
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