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Shape Memory Polymers for Active Cell Culture
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A Processable Shape Memory Polymer System for Biomedical Applications.

Keith Hearon1, Mark A Wierzbicki1, Landon D Nash1

  • 15045 Emerging Technologies Building, Department of Biomedical Engineering, 3120 Texas A&M University, College Station, TX, 77843-3120, USA.

Advanced Healthcare Materials
|May 1, 2015
PubMed
Summary
This summary is machine-generated.

New polyurethane shape memory polymers (SMPs) offer tunable thermomechanical properties for advanced medical devices. UV-catalyzed "click" reactions enable precise control over crosslinking for microactuator applications.

Keywords:
biomedical devicespolyurethaneshape memory polymersstructure-property relationshipsthiol-ene “click” chemistry

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Shape memory polymers (SMPs) are advanced materials with the ability to recover their original shape when subjected to a stimulus.
  • Polyurethane SMPs offer a promising platform for developing smart materials due to their versatile properties and biocompatibility.
  • Developing SMPs with precisely controlled thermomechanical properties and advanced processing capabilities is crucial for innovative medical device applications.

Purpose of the Study:

  • To synthesize and characterize polyurethane shape memory polymers (SMPs) with tunable thermomechanical properties.
  • To demonstrate the use of UV-catalyzed thiol-ene "click" reactions for postpolymerization crosslinking and control over crosslink density.
  • To implement these advanced SMPs in the design and fabrication of a microactuator medical device prototype.

Main Methods:

  • Synthesis of polyurethanes with varying C=C functionalization.
  • Solution blending with polythiol crosslinking agents and photoinitiator.
  • UV irradiation to induce postpolymerization crosslinking.
  • Thermomechanical characterization including glass transition temperature (Tg) and rubbery modulus determination.
  • Fabrication of a laser-actuated SMP microgripper device.

Main Results:

  • Tunable glass transition temperatures (Tg) ranging from 30 to 105 °C.
  • Tailorable rubbery moduli from 0.4 to 20 MPa.
  • High toughness exceeding 90 MJ m(-3) for low crosslink density formulations.
  • Successful fabrication of an SMP microgripper with an average gripping force of 1.43 ± 0.37 N.
  • Demonstrated in vitro deployment under simulated physiological conditions.

Conclusions:

  • UV-catalyzed thiol-ene "click" chemistry provides effective postpolymerization crosslinking for polyurethane SMPs.
  • This approach allows precise control over thermomechanical properties and toughness.
  • The developed SMP system exhibits advanced processing capabilities suitable for microactuator medical devices.
  • The SMP microgripper prototype shows potential for minimally invasive endovascular device delivery.