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Monkeys and Rats Are Not Susceptible to Ferret Hepatitis E Virus Infection
Tian-Cheng Li1, Sayaka Yoshizaki, Yasushi Ami
1Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan.
Intervirology
|May 1, 2015
Abstract:
Ferret hepatitis E virus (HEV), a novel hepatitis E-like virus, has been identified in ferrets in the Netherlands, Japan, and the US. To determine whether ferret HEV transmits to other animals, we inoculated laboratory rats (Wistar), nude rats (Long-Evans-rnu/rnu), and cynomolgus monkeys with ferret HEV (F4351) by intravenous injection. None of the animals demonstrated a positive sign for virus replication, indicating that rats and monkeys are not susceptible to ferret HEV.

