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Increased Prevalence of Sleep Apnea in Children with Pseudohypoparathyroidism Type 1a

Hannah Landreth1, Beth A Malow, Ashley H Shoemaker

  • 1University of Oklahoma School of Medicine, Norman, Okla., USA.

Hormone Research in Paediatrics
|May 1, 2015
PubMed

Insights

Children with pseudohypoparathyroidism type 1a (PHP1a) have a significantly higher risk of sleep apnea. This suggests that screening for sleep apnea in children with PHP1a is important for preventing health issues.

Area of Science:

  • Pediatric Endocrinology
  • Sleep Medicine
  • Genetics

Background:

  • Pseudohypoparathyroidism type 1a (PHP1a) is a rare genetic disorder.
  • Sleep disturbances and daytime somnolence are frequently reported in children with PHP1a.

Purpose of the Study:

  • To determine the prevalence of sleep apnea in children diagnosed with PHP1a.
  • To compare the risk of sleep apnea in PHP1a patients to a similarly obese control group.

Main Methods:

  • Prospective enrollment of 19 children (ages 2-21) with PHP1a.
  • Retrospective chart review of 18 additional PHP1a patients from a large de-identified database.
  • Utilized parent-reported sleep behavior surveys and polysomnography records where available.

Main Results:

  • Sleep disturbance (94%) and daytime somnolence (81%) were common in PHP1a patients.
  • 45% of PHP1a patients had a sleep apnea diagnosis, compared to 8.8% in an obese control group.
  • PHP1a patients with sleep apnea were significantly younger (8.1 years) than those without (12.8 years).

Conclusions:

  • Children with PHP1a exhibit a 4.4-fold increased relative risk for sleep apnea.
  • Routine screening for sleep apnea is recommended in pediatric PHP1a population.
  • Early detection and management of sleep apnea can prevent adverse health outcomes in PHP1a patients.
Abstract

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