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Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
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Altercasting is a strategic communication technique in which an individual imposes a specific identity or social role onto another person to influence their behavior and shape the interaction. By presuming a role—such as “responsible leader” or “patient person”—altercasting encourages the target to conform to that identity, often aligning their behavior with the expectations associated with the role. The power of this tactic lies in its subtlety; once a role...
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Microbial communities are dynamic environments where cell lysis releases free DNA into the surroundings. Other cells can take up this extracellular DNA through a process known as transformation.When a cell incorporates this foreign DNA into its genome, resulting in genetic modification, the process is known as transformation. Cells capable of this process are termed competent. Competence can be natural, as observed in certain bacteria and archaea, or artificially induced in the...
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The scale-up of microbial fermentation processes is essential in industrial biotechnology, allowing the transition from laboratory-scale experiments to commercial-scale production while aiming to maintain product yield and quality. This process requires meticulous adjustment of equipment design, process parameters, and contamination control strategies to accommodate increasing culture volumes.At the laboratory scale, cultures are typically maintained in 1 to 10-liter glass or autoclavable...
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The halo effect is a cognitive bias in which an individual's overall impression influences judgments about their specific traits. This psychological phenomenon leads people to associate positive characteristics with those they perceive as generally good and negative characteristics with those they view as bad. This effect is particularly influential in social perception, professional evaluations, and decision-making processes.The Psychological Basis of the Halo EffectThe halo effect is rooted...
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Transformations modify the graphical representation of a function without changing its fundamental form. One common transformation is reflection, which flips the graph across a designated axis. When the vertical coordinates of all points are multiplied by the negative one, the entire graph is mirrored over the horizontal axis. This transformation reverses the vertical orientation of peaks and troughs, akin to signal inversion in electrical systems, where a waveform is flipped, but the timing of...
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Transforming training to reflect the workforce

Ambika Mathur1, Frederick J Meyers1, Roger Chalkley1

  • 1Ambika Mathur is Dean of the Graduate School; Director, Office of Postdoctoral Affairs; and Professor of Pediatrics, Wayne State University, Detroit, MI 48202, USA.Frederick J. Meyers is Vice Dean of the School of Medicine, University of California, Davis, Sacramento, CA 95817, USA.Roger Chalkley is Senior Associate Dean for Biomedical Research, Education, and Training; Professor of Molecular Physiology and Biophysics; and Professor of Medical Education and Administration, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.Theresa C. O'Brien is Associate Chancellor, University of California, San Francisco, San Francisco, CA 94143, USA.Cynthia N. Fuhrmann is Assistant Dean, Career and Professional Development in the Graduate School of Biomedical Sciences and Assistant Professor, Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA. Corresponding author.

Science Translational Medicine
|May 1, 2015
PubMed
Summary

No abstract available in PubMed .

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