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The first Malay database toward the ethnic-specific target molecular variation.

Hashim Halim-Fikri1,2, Ali Etemad3, Ahmad Zubaidi Abdul Latif4

  • 1Department of Pediatric, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Kelantan, Malaysia. halimfikri@gmail.com.

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Summary

The Malaysian Node of the Human Variome Project (MyHVP) database stores genetic variations in Malays, aiding population genomics and disease research. It will expand to include other Malaysian ethnic groups, offering valuable insights for diverse populations.

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Area of Science:

  • Genomics
  • Population Genetics
  • Bioinformatics

Background:

  • The Malaysian Node of the Human Variome Project (MyHVP) coordinates genotypic and phenotypic variation studies in Malaysia.
  • A specialized ethnic-specific database, MyHVPDb, was developed to manage genetic variation data associated with health and disease in Malaysian ethnic groups.

Purpose of the Study:

  • To establish a centralized repository for Malaysian population genetic variation data.
  • To support research on genomics and genetic diseases within Malaysia.

Main Methods:

  • Development of a specialized database (MyHVPDb) for storing and managing genetic variation data.
  • Data organization based on genetic variations, diseases, and mutation types (SNP, CNV).

Main Results:

  • MyHVPDb currently contains genetic variation and mutation data for the Malay population.
  • The database categorizes data into Single Nucleotide Polymorphisms (SNP), Copy Number Variations (CNV), and common disease-related mutations.
  • Access to MyHVPDb is available to local researchers, academicians, and students via the MyHVP portal.

Conclusions:

  • MyHVPDb serves as a valuable resource for clinicians and researchers studying population genomics and genetic diseases.
  • The database provides up-to-date, accurate information on population-specific variations.
  • Findings are relevant for countries with similar ethnic backgrounds.