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Related Experiment Video

Updated: Apr 13, 2026

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Does BDNF Val66Met Polymorphism Confer Risk for Posttraumatic Stress Disorder?

Tengfei Wang1

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This meta-analysis found no significant link between the brain-derived neurotrophic factor (BDNF) Val66Met gene variant and posttraumatic stress disorder (PTSD) risk. Control group stress status may influence this association, warranting further research.

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • The brain-derived neurotrophic factor (BDNF) Val66Met genetic variant has been implicated in posttraumatic stress disorder (PTSD) development.
  • Previous studies on the association between BDNF polymorphism and PTSD risk have yielded conflicting results.
  • This meta-analysis aimed to clarify the relationship between BDNF Val66Met and PTSD susceptibility.

Purpose of the Study:

  • To evaluate the association between the BDNF Val66Met genetic variant and the risk of developing PTSD.
  • To synthesize existing evidence through a comprehensive meta-analysis.

Main Methods:

  • Systematic literature searches were conducted across major online databases.
  • Six relevant studies were included, and pooled analyses were performed using various genetic inheritance models.
  • Subgroup and sensitivity analyses, including assessments based on Hardy-Weinberg equilibrium (HWE), were performed.

Main Results:

  • No significant overall association was found between the BDNF Val66Met variant and PTSD susceptibility across different genetic models.
  • Subgroup analyses indicated that the stress status of control groups, rather than ethnicity, might modulate the BDNF Val66Met-PTSD risk relationship.
  • Exclusion of a study not in HWE did not alter the study's main conclusions.

Conclusions:

  • The meta-analysis suggests no direct genetic association between the BDNF Val66Met variant and PTSD vulnerability.
  • Further research is necessary to elucidate the precise role of BDNF variants in PTSD occurrence.