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Updated: Apr 13, 2026

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Spatial QT Dispersion Predicts Nonsustained Ventricular Tachycardia and Correlates with Confined Systodiastolic

Damiano Magrì1, Gianfranco Piccirillo, Agnese Ricotta

  • 1Department of Clinical and Molecular Medicine, 'Sapienza' University, Rome, Italy.

Cardiology
|May 1, 2015
PubMed

Insights

Increased dispersion of repolarization, specifically QTc interval dispersion (QTe dispersion), is linked to nonsustained ventricular tachycardia (NSVT) in hypertrophic cardiomyopathy (HCM) patients. This electrical instability may correlate with impaired myocardial function.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Cardiovascular Imaging

Background:

  • Hypertrophic cardiomyopathy (HCM) is associated with an increased risk of arrhythmias.
  • Dispersion of myocardial repolarization is a key mechanism contributing to this arrhythmic risk.

Purpose of the Study:

  • To investigate spatial myocardial repolarization dispersion indices in HCM patients.
  • To identify clinical determinants of nonsustained ventricular tachycardia (NSVT) in HCM.

Main Methods:

  • Fifty-two HCM outpatients were divided into NSVT and non-NSVT groups based on 24-hour Holter ECG.
  • Patients underwent clinical examination, Doppler echocardiography, cardiac MRI, and 12-lead ECG.
  • Calculated dispersion for QRS, Q-Tend (QTe), Q-Tpeak, Tpeak-Tend (TpTe), J-Tpeak, and J-Tend intervals.

Main Results:

  • HCM patients with NSVT exhibited significantly higher QTe dispersion and Tpeak-Tend (TpTe) dispersion.
  • Late gadolinium enhancement and QTe Bazett dispersion independently predicted NSVT occurrence.
  • QTe dispersion showed a strong association with myocardial performance index (MPI) in the interventricular septum.

Conclusions:

  • QTe dispersion serves as a noninvasive tool for identifying HCM patients at risk for NSVT.
  • A link between electrical instability and localized systodiastolic dysfunction in HCM is suggested by the QTe dispersion-MPI relationship.
Abstract

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