Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

87.8K
Overview
87.8K
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

3.7K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
3.7K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

1.1K
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
1.1K
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.6K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.6K
Histology of the Small Intestine01:27

Histology of the Small Intestine

5.1K
The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
5.1K
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

4.6K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A predisposing effect of HLA class II genes in celiac disease by skewing the naive CD4<sup>+</sup> T cell receptor repertoire.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Celiac disease plasma cells recognize the active form of transglutaminase 2 with and without bound substrate.

Journal of autoimmunity·2026
Same author

The Low FODMAP Diet in Celiac Disease: 5-Year Follow-Up of a Randomized Controlled Trial.

Gastro hep advances·2026
Same author

Exploring Autologous Dendritic Cells for T Cell Modulation: A Step Towards Personalized Medicine in Leishmaniasis.

Cells·2026
Same author

Upcoming Treatments in Celiac Disease: From Luminal Enzymes to Oral Immune Tolerance.

United European gastroenterology journal·2026
Same author

A model for predicting celiac disease among undiagnosed subjects established with data from the HUNT4 study.

BMC gastroenterology·2026

Related Experiment Video

Updated: Apr 13, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

25.1K

Small bowel, celiac disease and adaptive immunity.

Ludvig M Sollid, Rasmus Iversen, Øyvind Steinsbø

    Digestive Diseases (Basel, Switzerland)
    |May 1, 2015
    PubMed
    Summary

    Celiac disease involves an immune response to gluten, with HLA-DQ2/DQ8 genes playing a key role. Understanding the link between transglutaminase 2 (TG2) and gluten is crucial for new treatments.

    More Related Videos

    Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
    07:34

    Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

    Published on: December 16, 2021

    3.3K
    Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
    06:57

    Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

    Published on: September 18, 2016

    9.7K

    Related Experiment Videos

    Last Updated: Apr 13, 2026

    Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
    10:27

    Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

    Published on: December 15, 2011

    25.1K
    Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
    07:34

    Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

    Published on: December 16, 2021

    3.3K
    Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells
    06:57

    Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

    Published on: September 18, 2016

    9.7K

    Area of Science:

    • Immunology
    • Genetics
    • Gastroenterology

    Background:

    • Celiac disease is a multifactorial autoimmune disorder triggered by gluten ingestion.
    • Current treatment relies on strict gluten elimination, highlighting the need for alternative therapies.

    Purpose of the Study:

    • To explore the genetic and immunological underpinnings of celiac disease.
    • To investigate the role of specific genes and immune responses in disease development.

    Main Methods:

    • Analysis of genetic factors, focusing on Major Histocompatibility Complex (MHC) genes.
    • Examination of immune responses, including T cell activation and antibody production.

    Main Results:

    • HLA-DQ2 and HLA-DQ8 are the primary genetic factors, presenting gluten epitopes to CD4+ T cells.
    • Transglutaminase 2 (TG2) deamidates gluten epitopes, and TG2 autoantibodies are specific to celiac disease.
    • Antibodies to deamidated gluten are also highly specific, appearing in genetically susceptible individuals consuming gluten.

    Conclusions:

    • Adaptive immunity, particularly T cell responses mediated by HLA-DQ2/DQ8, is central to celiac disease pathogenesis.
    • The dual role of TG2 in epitope formation and as an autoantigen target requires further investigation.
    • Understanding the TG2-gluten connection is key to elucidating gluten-induced tissue damage in celiac disease.