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A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
Published on: January 11, 2015
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Metabolomics in chemical ecology
Constanze Kuhlisch1, Georg Pohnert
1Friedrich Schiller University, Institute of Inorganic and Analytical Chemistry, Lessingstr. 8, D-07743 Jena, Germany. Georg.Pohnert@uni-jena.de.
Natural Product Reports
|May 1, 2015
Summary
Metabolomics, a powerful tool in chemical ecology, identifies natural products mediating organism interactions. Linking metabolomics with other -omics technologies reveals biosynthetic pathways and genetic responses in ecological interactions.
Area of Science:
- Chemical ecology
- Metabolomics
- Systems biology
Background:
- Natural products mediate organismal interactions.
- Metabolomics offers new opportunities to study signaling molecules.
- Comparative metabolomics aids in identifying regulated compounds.
Purpose of the Study:
- Highlight successful applications of metabolomics in chemical ecology.
- Discuss limitations of metabolomics techniques.
- Explore metabolomics in systems biology of organismal interactions.
Main Methods:
- Comparative metabolomics for identifying interaction-regulated compounds.
- Integration of metabolomics with other -omics techniques.
- Analysis of metabolic profiles of interacting organisms.
Main Results:
- Metabolomics overcomes limitations of traditional bioassay-guided approaches.
- Metabolomics, linked with other -omics, reveals biosynthetic and genetic re-wiring.
- Successful applications in studying pheromones, allelochemicals, and defenses.
Conclusions:
- Metabolomics is a powerful approach in chemical ecology.
- Future potential of large metabolomics initiatives for model organisms.
- Advancing the understanding of organismal interactions through metabolomics.
