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Role of prebiotics and probiotics in pediatric diseases

Sabrina Cardile1, Tommaso Alterio, Teresa Arrigo

  • 1Department of Pediatric Sciences, University of Messina, Messina, Italy - t.alterio@gmail.com.

Minerva Pediatrica
|May 1, 2015
PubMed

Insights

Probiotics and prebiotics modulate gut flora, offering benefits but requiring cautious use, especially in immunocompromised individuals. Further research is needed to define optimal applications and dosages for various conditions.

Area of Science:

  • Microbiology
  • Gastroenterology
  • Human Health

Background:

  • Growing understanding of gut microflora's role in human health.
  • Increased use of probiotics and prebiotics for gut flora modulation.
  • Concerns regarding indiscriminate use and safety in specific populations.

Purpose of the Study:

  • To review the current applications and safety considerations of probiotics and prebiotics.
  • To highlight evidence-based uses and areas needing further research.
  • To emphasize prudent usage, particularly in vulnerable patient groups.

Main Methods:

  • Literature review on the efficacy and safety of probiotics and prebiotics.
  • Analysis of current clinical evidence for various health conditions.
  • Assessment of risks associated with probiotic use in specific patient populations.

Main Results:

  • Probiotics and prebiotics demonstrate benefits in certain conditions like viral gastroenteritis and antibiotic-associated diarrhea in children.
  • Evidence supports their use in pouchitis and mild ulcerative colitis.
  • Indiscriminate use is noted, with significant risks in immunocompromised patients, including sepsis.

Conclusions:

  • Probiotic and prebiotic use is beneficial but requires careful consideration of strain specificity and patient condition.
  • Prudent application is essential, especially for immunocompromised individuals and those with severe chronic diseases.
  • Further studies are required to establish optimal dosages and treatment durations for various clinical indications.

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