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Somatostatin receptor 1-5; expression profiles during rat development.

Eva Ludvigsen1, Carina Carlsson, Eva Tiensuu Janson

  • 1Department of Medical Cell Biology, Uppsala University , Uppsala , Sweden.

Upsala Journal of Medical Sciences
|May 1, 2015
PubMed
Summary

Somatostatin receptors (SSTRs) are present in developing rat embryos, with varying expression patterns. Specific SSTRs show distinct roles in pancreas development and differentiation.

Keywords:
DevelopmentmRNA expressionpancreasrat embryosomatostatin receptors

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Area of Science:

  • Developmental biology
  • Endocrinology
  • Molecular biology

Background:

  • Somatostatin acts via five receptor subtypes (SSTRs 1-5).
  • Understanding SSTRs' role in embryonic development is crucial.

Purpose of the Study:

  • Investigate SSTR mRNA expression and protein distribution in rat embryos.
  • Focus on the pancreas during embryonic development.

Main Methods:

  • Collected rat embryos at multiple developmental stages (days 10-21 and birth).
  • Utilized RT-PCR for mRNA analysis and immunohistochemistry for protein localization.

Main Results:

  • SSTR5 mRNA was absent in whole embryos; SSTR1-5 proteins were detected from day 10.
  • SSTR protein presence increased in skin and cartilage, remained stable in heart and liver.
  • Fetal pancreas showed SSTR2 and SSTR4 mRNA from day 14; SSTR1 protein co-localized with islet hormones; SSTR2 excluded from beta-cells; SSTR3-5 localized with specific islet hormones.

Conclusions:

  • SSTRs play a role in rat embryo development.
  • Further studies can clarify the regulatory functions of SSTRs in pancreas and organ growth/differentiation.