Osteosarcoma in Baboons (Papio spp)
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Updated: Apr 13, 2026

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
Published on: October 28, 2021
Marguerite J Mezzles1, Edward J Dick2, Michael A Owston2
1Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, Texas, USA; Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, USA.
Abstract:
Bone neoplasms in baboons (Papio spp) are rare, with only one confirmed case of osteosarcoma previously described in the literature. Over a 12-y period, 6 baboons at a national primate research center presented with naturally occurring osteosarcoma; 3 lesions affected the appendicular skeleton, and the remaining 3 were in the head (skull and mandible). The 6 cases presented were identified in members of a large outdoor-housed breeding colony. The subjects were not genetically related or exposed to the same research conditions. Diagnoses were made based on the presentation and radiographic findings, with histologic confirmation.
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