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Tracking the Brain's Functional Coupling Dynamics over Development.

R Matthew Hutchison1, J Bruce Morton2

  • 1Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, and.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|May 1, 2015
PubMed
Summary
This summary is machine-generated.

Brain development involves dynamic network changes impacting cognition. As individuals mature, the brain modifies functional variability to meet cognitive demands during rest and tasks.

Keywords:
brain statescognitive controlfMRIneural noiseresting state

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Cognitive Neuroscience

Background:

  • Human development involves significant brain transformations affecting cognition and behavior.
  • Understanding dynamic brain changes during this transition is crucial.

Purpose of the Study:

  • To investigate dynamic changes in functional brain network coupling during human development.
  • To examine how brain configurations and their temporal dynamics change from childhood to adulthood during rest and cognitive tasks.

Main Methods:

  • Utilized functional imaging to analyze brain network coupling strength.
  • Assessed the expression and temporal features of discrete brain configurations across age groups.
  • Compared brain dynamics during resting-state and a cognitive control task.

Main Results:

  • The brain's functional states were largely consistent across ages, but their temporal dynamics varied.
  • Increasing age correlated with increased connection strength variability at rest.
  • During cognitive control, higher-order networks showed an inverted pattern of variability with age.

Conclusions:

  • Brain development involves age-dependent modifications in dynamic functional connectivity.
  • These modifications help regulate functional variability to suit cognitive and behavioral demands.
  • Developmental changes optimize brain function for task performance and adaptive behavior.