Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

8.7K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.7K
The Functions of the Skeletal System01:22

The Functions of the Skeletal System

7.5K
The most apparent functions of the skeletal system are support, protection, and movement. However, bone tissue also performs several other critical metabolic functions. For one, the bone matrix acts as a reservoir for a number of minerals important to the functioning of the body, especially calcium and phosphorus. These minerals, present in the bone tissue, can be released back into the bloodstream when required. Calcium ions, for example, are essential for muscle contractions and controlling...
7.5K
What is the Skeletal System?01:02

What is the Skeletal System?

59.4K
Overview
59.4K
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

2.4K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
2.4K
Spongy Bone01:09

Spongy Bone

13.7K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
13.7K
Bone as Supporting Connective Tissue01:23

Bone as Supporting Connective Tissue

8.2K
Bone tissue forms the internal skeleton of vertebrate animals, providing structure to the body.
Bone Matrix
Bone, or osseous tissue, is a connective tissue that has a large amount of two different types of matrix material. The organic matrix is similar to the matrix material found in other connective tissues, including some amount of collagen and elastic fibers. This gives strength and flexibility to the tissue. The inorganic matrix consists of mineral salts— mostly calcium salts—...
8.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In-depth Human Phenotype Ontology Curation Boosts Prioritization Performance for Netherton Syndrome.

The British journal of dermatology·2026
Same author

Cardiomyopathy and Sudden Cardiac Death as a Rare Presentation of Mucolipidosis Type III in a Family With Compound Heterozygous Variants in <i>GNPTAB</i>.

Circulation. Genomic and precision medicine·2026
Same author

Data-driven prioritization of mouse strains for improved preclinical modeling of rare and common disease.

bioRxiv : the preprint server for biology·2026
Same author

Diagnostic utility of clinical genome reanalysis in rare pediatric disorders using long-read sequencing.

HGG advances·2026
Same author

Familial Robertsonian Translocation, rob(14;21), with High Risk for Down Syndrome.

Cytogenetic and genome research·2026
Same author

Systematic benchmarking demonstrates large language models have not reached the diagnostic accuracy of traditional rare-disease decision support tools.

European journal of human genetics : EJHG·2026
Same journal

Immune biomarkers, profiles, and responses: a vaccine ontology perspective.

Journal of biomedical semantics·2026
Same journal

A pragmatist approach to bridging tables and ontologies through LinkML and punning.

Journal of biomedical semantics·2026
Same journal

FAIR in practice: minimum metadata schema for bioinformatics analytics by machines.

Journal of biomedical semantics·2026
Same journal

Prenatal monitoring in primary health care: a design science research-based approach to FHIR interoperability.

Journal of biomedical semantics·2026
Same journal

From narrative evidence to computable knowledge: a decision-relevant corpus for medicinal herb-disease relationships.

Journal of biomedical semantics·2026
Same journal

BERTopic-driven term extraction from biomedical texts toward ontology population: evaluating vaccine ontology with Plotkin's vaccines corpus.

Journal of biomedical semantics·2026
See all related articles

Related Experiment Video

Updated: Apr 13, 2026

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

89.8K

Capturing domain knowledge from multiple sources: the rare bone disorders use case.

Tudor Groza1, Tania Tudorache2, Peter N Robinson3

  • 1School of ITEE, The University of Queensland, St Lucia, Australia.

Journal of Biomedical Semantics
|May 1, 2015
PubMed
Summary
This summary is machine-generated.

This study presents a novel approach for integrating diverse biomedical knowledge from multiple sources, creating a unified resource. The Rare Bone Disorders Ontology (RBDO) enables comprehensive querying and understanding of rare bone disorder data.

More Related Videos

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

4.0K
Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

18.5K

Related Experiment Videos

Last Updated: Apr 13, 2026

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

89.8K
Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
06:59

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model

Published on: September 8, 2023

4.0K
Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

18.5K

Area of Science:

  • Biomedical Informatics
  • Knowledge Representation
  • Ontology Engineering

Background:

  • Ontologies are crucial for formalizing complex biomedical information.
  • Current community-driven curation overlooks parallel conceptualizations from different groups.
  • A mechanism is needed to integrate diverse perspectives into a coherent overview.

Purpose of the Study:

  • To develop a method for the loose integration of biomedical knowledge from disparate sources.
  • To create a single, coherent, and interoperable knowledge resource.
  • To enable comprehensive analysis of domain knowledge from multiple viewpoints.

Main Methods:

  • Introducing an approach for loose integration of knowledge from diverse sources.
  • Implementing granular-level provenance tracking for original knowledge statements.
  • Developing the Rare Bone Disorders Ontology (RBDO) as a case study.

Main Results:

  • Demonstrated a method for creating a unified, interoperable knowledge resource.
  • RBDO facilitates answering queries about shared phenotypes across sources.
  • Enables understanding of disorder similarities based on divergent classifications.

Conclusions:

  • The proposed approach effectively integrates heterogeneous biomedical knowledge.
  • Granular provenance tracking ensures data integrity and traceability.
  • RBDO enhances research capabilities in rare bone disorders by enabling complex queries and comparative analyses.