Rationale and study design for an individualized perioperative open lung ventilatory strategy (iPROVE): study...

Area of Science:

• Anesthesiology
• Critical Care Medicine
• Thoracic Surgery

Background:

• Postoperative complications increase surgical patient morbidity and mortality.
• Current protective lung ventilation strategies are not always individualized.
• A global perioperative approach is needed for lung protection.

Purpose of the Study:

• To compare postoperative complications using an individualized perioperative ventilatory strategy versus a standard strategy.
• To evaluate the efficacy of a personalized approach in major abdominal surgery.
• To assess the impact of individualized intraoperative and postoperative ventilation.

Main Methods:

• A prospective, multicenter, randomized controlled trial involving 1012 high-risk patients.
• Four groups: individualized perioperative, individualized intraoperative + postoperative CPAP, standard intraoperative + postoperative CPAP, and standard perioperative.
• Primary outcome: composite analysis of postoperative complications.

Main Results:

• Results are pending as this is a trial design abstract.
• The study aims to determine if individualized strategies reduce complications.
• Comparison between personalized and standard ventilation protocols will be analyzed.

Conclusions:

• The Individualized Perioperative Open-lung Ventilatory Strategy (iPROVE) trial is the first to investigate this approach.
• This study will provide critical data on preventing postoperative pulmonary complications.
• Findings could lead to personalized ventilation protocols in surgery.