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Thyroid and steroid receptors.

M Marugo1, G Torre, D Bernasconi

  • 1Cattedra di Andrologia, University of Genoa, Italy.

Journal of Endocrinological Investigation
|September 1, 1989
PubMed
Summary
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Estradiol and progesterone receptors (ER, PgR) are present in human thyroid tissues, both normal and pathological. Higher concentrations were found in the nuclear fraction, suggesting a potential physiological role in thyroid function.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Pathology

Background:

  • Estradiol and progesterone receptors (ER, PgR) are found in various human tissues, including neoplastic and non-neoplastic thyroid.
  • Understanding their presence and distribution in thyroid tissue is crucial for comprehending potential hormonal influences.

Purpose of the Study:

  • To quantify the content of ER and PgR in pathological non-malignant thyroid tissues (solitary adenoma, simple nontoxic goiter) and adjacent normal thyroid tissue.
  • To investigate the subcellular localization (cytosolic vs. nuclear) of these receptors.

Main Methods:

  • Analysis of cytosolic and nuclear fractions from thyroid tissue samples.
  • Detection and quantification of ER and PgR protein levels using appropriate assays.
  • Statistical analysis to compare receptor levels between different tissue types and patient demographics.

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Main Results:

  • ER and PgR were detected in most examined thyroid tissues, encompassing both pathological and normal samples.
  • Receptor levels were generally higher in the nuclear fraction compared to the cytosolic fraction.
  • Significant differences in nuclear ER levels were observed between adenomas and simple goiters, and between normal tissues adjacent to adenomas versus those in goiters.

Conclusions:

  • Estradiol and progesterone receptors are widely present in human thyroid tissue.
  • The nuclear localization suggests a potential role in thyroid cell function and regulation.
  • Further research is warranted to elucidate the precise physiological functions of these receptors in the thyroid gland.