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Neuronal Networks during Burst Suppression as Revealed by Source Analysis
Natia Japaridze1, Muthuraman Muthuraman2, Christine Reinicke1
1Department of Neuropediatrics, Christian-Albrechts-University, Kiel, Germany.
Plos One
|May 1, 2015
Summary
Burst-suppression (BS) involves alternating EEG patterns. Our study reveals distinct brain network activity during burst and suppression phases, suggesting cortical deafferentation may impact neurological outcomes.
Area of Science:
- Neuroscience
- Clinical Electrophysiology
Background:
- Burst-suppression (BS) is an EEG pattern seen in coma and anesthesia.
- While animal studies implicate cortex and thalamus, human BS mechanisms remain unclear.
Purpose of the Study:
- Identify the neuronal network underlying burst and suppression phases in human BS.
- Analyze functional and effective connectivity in EEG during BS.
Main Methods:
- Applied Dynamic Imaging of Coherent Sources (DICS) to EEG in 13 neonates/infants.
- Used Renormalized Partial Directed Coherence (RPDC) to analyze informational flow between brain sources.
Main Results:
- Burst phases showed coherent sources in thalamus, brainstem, and cortical regions (frontal, parietal).
- Suppression phases exhibited coherent sources solely in cortical regions.
- RPDC revealed upward informational flow from brainstem to thalamus and thalamus to cortex during bursts, absent during suppression.
Conclusions:
- Findings suggest a "cortical deafferentiation" between cortex and sub-cortical structures during suppression phases.
- This deafferentiation may correlate with poor neurological outcomes in encephalopathies.
