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Related Experiment Video

Updated: Apr 13, 2026

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression
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An internet-based adolescent depression preventive intervention: study protocol for a randomized control trial.

Tracy G Gladstone1, Monika Marko-Holguin2, Phyllis Rothberg3

  • 1Wellesley Centers for Women, Wellesley College, Central Street, Wellesley, MA, 20481, USA. tgladsto@wellesley.edu.

Trials
|May 1, 2015
PubMed
Summary
This summary is machine-generated.

This study evaluated CATCH-IT, an internet-based depression prevention program for adolescents, showing promise for accessible mental healthcare. The findings will guide future online interventions for at-risk youth.

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Area of Science:

  • Mental Health
  • Adolescent Psychology
  • Digital Health Interventions

Background:

  • Major depressive disorder affects many adolescents, with limited treatment success.
  • Internet-based interventions offer accessible, evidence-based solutions for adolescent depression.
  • Integrating digital health into primary care requires further research.

Purpose of the Study:

  • To evaluate the efficacy of a self-guided, online depression prevention program for adolescents.
  • To compare the CATCH-IT intervention with a general health education program.
  • To inform the development of future internet-based adolescent prevention programs.

Main Methods:

  • A randomized clinical trial was designed to evaluate the Competent Adulthood Transition with Cognitive Behavioral Humanistic and Interpersonal Training (CATCH-IT) program.
  • The study involves mass screening of primary care populations to identify at-risk adolescents.
  • The trial measures both symptomatic and diagnostic clinical outcomes.

Main Results:

  • Currently, 234 adolescents and 186 parents are enrolled across 6 major health systems.
  • The protocol represents a systematic approach to connecting at-risk youth with self-directed depression prevention.
  • The trial design incorporates both computer-based instruction and human contact.

Conclusions:

  • The CATCH-IT trial provides a model for a new generation of mental health interventions.
  • Results will inform guidelines for preventive interventions in at-risk youth.
  • This approach has the potential for broad generalizability in preventing mental disorders.