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Updated: Apr 13, 2026

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
09:44

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

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Autophagy and apoptosis in liver injury

Kewei Wang1

  • 1a Departments of Surgery; University of Illinois College of Medicine ; Peoria , IL , USA.

Cell Cycle (Georgetown, Tex.)
|May 1, 2015
PubMed

Keywords:
ALT, alanine aminotransferaseAMBRA-1, activating molecule in Beclin-1-regulated autophagyAPAP, N-acetyl-p-aminophenolATP, adenosine triphosphateAtg, autophagy-related geneBH3, Bcl-2 homology domain-3BNIP, Bcl-2/adenovirus E1B 19 kd-interacting proteinBarkor, Beclin-1-associated autophagy-related key regulatorBcl-2, B-cell lymphoma-2Bcl-xL, B-cell lymphoma extra longBeclin-1, Bcl-2-interacting protein-1CSE, cigarette smoke extractDISC, death-inducing signaling complexDNA, DNADRAM, damage regulated autophagic modulatorDrp1, dynamin-related protein 1ER stress, endoplasmic reticulum stressFADD, Fas-associated protein with death domainFFA, free fatty acidsHBV, hepatitis B virusHBx, hepatitis B X proteinHCC, hepatocellular carcinomaHCV, hepatitis C virusHSC, hepatic stellate cellsLAMP-2, lysosome-associated membrane protein 2LD, lipid dropletsMDBs, Mallory-Denk bodiesMOMP, mitochondrial outer membrane permiabilizationMicrotubule LC3, microtubule light chain 3PCD, programmed cell deathPI3KC3, phosphatidylinositol-3-kinase class-3RNA, ribonucleic acidROS, reactive oxygen speciesTNFα, tumor necrosis factor-αTUNEL, terminal deoxynucleotidyl transferase dUTP nick-end labelingUVRAG, UV-resistance-associated geneVps34, vacuolar protein sorting-34apoptosisautophagyc-FLIP, cellular FLICE-like inhibitor proteincross-talkliver injurymTOR, mammalian target of rapamycinmechanismsiRNA, small interfering RNA

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