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DEFENS - Drug Exposure Feedback and Education for Nurses' Safety: study protocol for a randomized controlled trial
Christopher R Friese1, Kari Mendelsohn-Victor2, Bo Wen3
1University of Michigan School of Nursing, 400 North Ingalls, #4162, Ann Arbor, MI, USA. cfriese@umich.edu.
Trials
|May 1, 2015
Summary
Oncology nurses
Area of Science:
- Occupational Health
- Nursing Practice
- Pharmacology
Background:
- Hazardous drug exposure poses health risks to oncology nurses.
- Low adherence to personal protective equipment (PPE) use is a concern.
- Previous interventions lack rigorous multi-site testing.
Purpose of the Study:
- To compare the efficacy of an audit and feedback intervention versus education alone.
- To increase nurses' self-reported use of PPE when handling hazardous drugs.
- To identify factors that may mediate or moderate intervention effects.
Main Methods:
- Cluster randomized controlled trial design.
- Recruitment of cancer centers and oncology nurses.
- Intervention delivery via a secure online platform.
- Primary endpoint: change in Revised Hazardous Drug Handling Questionnaire scores over 18 months.
- Measurement of hazardous drug levels in plasma.
Main Results:
- The DEFENS study is ongoing; results are pending.
- The study aims to provide data on intervention effectiveness.
Conclusions:
- Effective interventions are needed to protect oncology nurses from hazardous drug exposure.
- The DEFENS study will inform future safety practices.
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