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Murine Echocardiography of Left Atrium, Aorta, and Pulmonary Artery
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Murine left atrium and left atrial appendage structure and function: echocardiographic and morphologic evaluation.

Francesca Colazzo1, Laura Castiglioni2, Luigi Sironi3

  • 1Centro Cardiologico Monzino IRCCS, Milan, Italy.

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Summary

This study establishes an echocardiographic protocol to characterize the murine venous reservoir, including the left atrium and left atrial appendage, aiding in the assessment of cardiac function changes in myocardial infarction models.

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Area of Science:

  • Cardiovascular Research
  • Mouse Models
  • Echocardiography

Background:

  • The murine venous reservoir (left atrium, left atrial appendage, pulmonary veins) requires a standardized echocardiographic protocol for accurate assessment.
  • Understanding normal venous reservoir dimensions and function is crucial for detecting cardiac alterations.

Purpose of the Study:

  • To develop and validate an echocardiographic protocol for describing the normal murine venous reservoir.
  • To assess the utility of this protocol in identifying changes in the left atrium and left atrial appendage in a myocardial infarction model.

Main Methods:

  • Echocardiographic assessment of global left ventricular function and venous reservoir in C57BL/6N mice.
  • Detailed analysis of left atrium and left atrial appendage dimensions and velocities in different mouse strains.
  • Investigation of cardiac structure and function following induced myocardial infarction.

Main Results:

  • Established normal dimensions for the murine left atrium (5.2±1.4 μL) and left atrial appendage (4.1±0.5 mm).
  • Demonstrated that left atrial appendage flow and left atrial volume reservoir contribute significantly to stroke volume.
  • Successfully discriminated size increases in the left atrium and left atrial appendage following myocardial infarction.

Conclusions:

  • Developed an optimized echocardiographic protocol for comprehensive characterization of the murine left venous reservoir.
  • The protocol enables rapid and serial determination of cardiac structure and function, valuable for investigative and pharmacological studies.
  • This approach is effective in identifying cardiac changes in stress-induced models like myocardial infarction.