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Survivin expression in canine lymphomas in relation with proliferative markers
Polish Journal of Veterinary Sciences
|May 2, 2015
Summary
Survivin is commonly found in canine lymphomas and its expression correlates with proliferation in highly active tumor areas. This suggests survivin may be a potential therapeutic target for canine lymphoma.
Area of Science:
- Veterinary oncology
- Molecular biology
- Cancer research
Background:
- Survivin, an apoptosis inhibitor, is overexpressed in human cancers and linked to cell cycle regulation.
- While survivin's role in human lymphomas is studied, its expression in canine lymphomas is largely unknown.
Purpose of the Study:
- To investigate survivin expression in canine lymphomas.
- To correlate survivin expression with proliferation markers (mitotic index, Ki67).
Main Methods:
- Immunohistochemical analysis of survivin expression in 25 canine lymphoma samples across 6 subtypes.
- Quantification of survivin, mitotic index, and Ki67-positive cells.
- Analysis of survivin expression in relation to proliferation in both random and selected tumor areas.
Main Results:
- Survivin was expressed in all canine lymphomas, primarily with nuclear localization.
- Most lymphomas (18/25) showed 10-25% survivin-positive cells.
- High correlation between survivin expression and proliferation index was observed in highly proliferative tumor areas.
Conclusions:
- Survivin is commonly expressed in canine lymphomas, suggesting a role in cell cycle activation.
- The correlation in proliferative areas indicates survivin's potential involvement in canine lymphoma cell proliferation.
- Survivin may represent a potential therapeutic target for canine lymphomas.
