Large granular lymphoma in six cats

Area of Science:

• Veterinary Oncology
• Hematopathology

Background:

• Large granular lymphoma (LGL) is a distinct lymphoma category characterized by neoplastic cells with visible cytoplasmic granules.
• Feline LGLs present in various forms, including nasal, systemic, and alimentary.

Purpose of the Study:

• To document clinical and cytological data of feline LGL.
• To analyze therapeutic responses in treated feline LGL cases.

Main Methods:

• Retrospective case review of six cats diagnosed with LGL between 2012-2014.
• Cytological sample collection via fine-needle biopsy for diagnosis.
• Treatment analysis including palliative glucocorticoids, COP chemotherapy, and masitinib.

Main Results:

• Alimentary form was most common (4/6 cats).
• Median survival: 9 months for chemotherapy, 1.5 months for glucocorticoids.
• Conventional chemotherapy showed good response in some cases.

Conclusions:

• Feline LGL, particularly the alimentary form, is relatively common.
• Standard diagnostic methods (clinical, imaging, cytology) are sufficient.
• Conventional chemotherapy can yield positive outcomes despite aggressive nature.