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Tenofovir in Indian children

Jagdish Kathwate1, Ira Shah

  • 1Pediatric HIV, TB and Liver Clinic, Bai Jerbai Wadia Hospital for Children, Mumbai, India. docjagdishkat@gmail.com.

Indian Pediatrics
|May 2, 2015
PubMed

Insights

Tenofovir-based antiretroviral therapy is safe and effective for HIV-infected children in India. This treatment showed no adverse effects or treatment failures over an average 3.4-year follow-up period in young patients.

Area of Science:

  • Pediatric infectious diseases
  • Antiretroviral therapy research
  • HIV/AIDS clinical management

Background:

  • Antiretroviral therapy (ART) is crucial for managing HIV infection in children.
  • Treatment failure or adverse effects necessitate switching to second-line ART regimens.
  • Tenofovir is a key component in many modern ART regimens.

Purpose of the Study:

  • To evaluate the safety and efficacy of tenofovir-based ART in Indian children with HIV.
  • To assess treatment outcomes after failure or intolerance to first-line ART.
  • To determine the renal and gastrointestinal safety profile of tenofovir in this pediatric population.

Main Methods:

  • Retrospective analysis of seven HIV-infected children.
  • Treatment with tenofovir-based antiretroviral therapy.
  • Follow-up for an average of 3.4 years.
  • Monitoring for adverse effects and treatment failure.

Main Results:

  • No adverse effects were reported in any of the seven children during the follow-up period.
  • No instances of treatment failure were observed.
  • Tenofovir demonstrated a favorable safety profile regarding renal and gastrointestinal health.

Conclusions:

  • Tenofovir-based ART is a safe and effective second-line treatment option for HIV-infected Indian children and adolescents.
  • The drug exhibits good renal and gastrointestinal tolerability in this population.
  • This supports the continued use of tenofovir in pediatric HIV management.

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