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Related Experiment Video

Updated: Apr 13, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Tract-Based Spatial Statistics in Preterm-Born Neonates Predicts Cognitive and Motor Outcomes at 18 Months.

E G Duerden¹, J Foong¹, V Chau²

¹From the Department of Paediatrics (E.G.D., J.F., V.C., H.B., S.P.M.), Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.

AJNR. American Journal of Neuroradiology

|May 2, 2015

Summary

Early diffusion MR imaging in preterm infants shows limited prediction of neurodevelopment. Later scans, closer to term-equivalent age, better predict motor and cognitive outcomes using fractional anisotropy. Brain dysmaturation impacts these associations.

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A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

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Published on: November 3, 2016

Area of Science:

Neuroimaging
Developmental Neuroscience
Neonatology

Background:

Adverse neurodevelopmental outcomes are frequent in preterm infants.
Sensitive early predictors of neurodevelopment are crucial for intervention.
Tract-based spatial statistics (TBSS) using diffusion MRI shows promise.

Purpose of the Study:

To assess the association between early TBSS findings and neurodevelopmental outcomes at 18 months corrected age.
To compare the predictive power of early versus later diffusion MRI scans.

Main Methods:

180 preterm neonates (24-32 weeks gestation) underwent diffusion tensor imaging (DTI) at two time points: early (32 weeks postmenstrual age) and late (term-equivalent age).
Tract-based spatial statistics (TBSS) analysis was performed on aligned DTI data.
Neurodevelopmental assessment at 18 months corrected age used Bayley Scales and Peabody Developmental Motor Scales.

Main Results:

Early DTI scans (30-33 weeks) showed limited association between motor skills and diffusivity measures in specific white matter tracts.
Later DTI scans (37-41 weeks) revealed significant relationships between motor/cognitive scores and fractional anisotropy in the corpus callosum and corticospinal tracts.
TBSS in very preterm infants (<30 weeks) did not significantly predict outcomes.

Conclusions:

The association between fractional anisotropy and neurodevelopmental scores strengthens from early to later scans in preterm infants.
This suggests brain dysmaturation in preterm infants influences the predictive value of diffusion MRI findings.