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Primary High-Grade Poorly Differentiated Angiosarcoma of an Intra-parotid Lymph Node
Eugenia Ducharne-Asuaje1, Dominique Dorion2, Louis Lamarre3
1Pathology Department, Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke University, 3001, 12e Avenue Nord, Sherbrooke, QC, J1H 5N4, Canada. eugenia.ducharne.asuaje@usherbrooke.ca.
Head and Neck Pathology
|May 2, 2015
Summary
This case report details a rare primary high-grade angiosarcoma within a parotid lymph node. Immunohistochemical stains confirmed the diagnosis, highlighting this tumor
Area of Science:
- Oncology
- Pathology
- Head and Neck Surgery
Background:
- Head and neck angiosarcoma is a rare vascular malignancy.
- Typically, angiosarcomas in this region are metastatic.
- Primary intra-parotid lymph node angiosarcoma is exceptionally uncommon.
Observation:
- A 47-year-old man presented with a 6-month history of a painless parotid mass.
- Imaging revealed a 17 mm left parotid lesion.
- Initial fine needle aspiration was inconclusive, suggesting lymphoma or carcinoma.
Findings:
- Histopathology confirmed a poorly differentiated, high-grade angiosarcoma within an intra-parotid lymph node.
- Tumor cells exhibited epithelioid morphology and atypical mitoses.
- Immunohistochemistry was positive for Vimentin, CD31, D2-40, factor VIII, ERG, and CD34.
Implications:
- This case underscores the importance of considering rare diagnoses in head and neck masses.
- Immunohistochemistry is crucial for differentiating angiosarcoma from other neoplasms.
- Accurate diagnosis of primary intra-parotid angiosarcoma is vital for appropriate management and prognosis.
