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Related Experiment Video

Updated: Apr 13, 2026

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Nanoparticle-stabilized microbubbles for multimodal imaging and drug delivery.

Ýrr Mørch1, Rune Hansen2, Sigrid Berg2

  • 1SINTEF Materials and Chemistry, P.O. Box 4760 Sluppen, 7465, Trondheim, Norway.

Contrast Media & Molecular Imaging
|May 2, 2015
PubMed
Summary

Researchers developed novel microbubbles (MBs) coated with nanoparticles for enhanced ultrasound imaging and targeted drug delivery. These multifunctional MBs offer improved therapy and contrast compared to traditional methods.

Keywords:
focused ultrasoundmicrobubblenanoparticlepoly(butyl cyanoacrylate)targeted drug deliverytheranostics

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Medical Imaging

Background:

  • Microbubbles (MBs) are standard ultrasound contrast agents.
  • MBs combined with ultrasound show potential for enhanced drug delivery.
  • Existing technologies lack integrated imaging and therapeutic capabilities.

Purpose of the Study:

  • To develop a multifunctional platform combining imaging and therapy using nanoparticle-stabilized MBs.
  • To create a system for enhanced drug delivery and improved diagnostic contrast.
  • To demonstrate the potential for multimodal imaging (ultrasound, MRI).

Main Methods:

  • Developed polyethylene glycol (PEG)-coated poly(butyl cyanoacrylate) (PBCA) nanoparticles (NPs) encapsulating drugs/contrast agents.
  • Prepared MBs stabilized by self-assembled NPs at the air-liquid interface.
  • Demonstrated ultrasound imaging capabilities and triggered NP release using specific ultrasound pulses.
  • Confirmed encapsulation of iron oxide NPs within PBCA NPs.

Main Results:

  • Successfully created NP-stabilized MBs functioning as ultrasound contrast agents.
  • Demonstrated the potential for multimodal imaging through iron oxide NP encapsulation.
  • Showcased triggered release of NPs from MBs upon ultrasound application.
  • Indicated potential for increased local NP deposit in target tissues.

Conclusions:

  • Developed a novel, multifunctional NP-MB platform for integrated imaging and therapy.
  • The platform offers enhanced ultrasound imaging and targeted drug delivery capabilities.
  • Potential for multimodal imaging and improved therapeutic outcomes compared to free NPs.