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Surgical Procedures and Methodology for a Preclinical Murine Model of De Novo Mammary Cancer Metastasis
Published on: July 29, 2017
[Metastatic screening before adjuvant chemotherapy in breast cancer]
Cyrielle Thonnon1, Christelle Faure1, Nicolas Chopin1
1Centre Léon-Bérard, département de chirurgie cancérologique-sein, 28, rue Laennec, 69373 Lyon cedex 08, France.
Introduction:
Systematic metastasis staging in early breast cancer is no longer recommended. However, it is still performed before adjuvant chemotherapy.
Materials And Methods:
We assessed metastasis screening of asymptomatic women with a local breast cancer without lymph node involvement when adjuvant chemotherapy was indicated. The screening result was classified in 3 groups: "non-metastatic", "metastatic" and "suspect". For suspect screening, we analyzed the checking period and the consequences on cares.
Results:
Out of 1545 patients with possible indication of chemotherapy, 690 indications of chemotherapy were validated by multidisciplinary meeting. Six hundred and thirty-nine metastasis screening were done. Five hundred and fifty-five screenings (86.9 %) were "non-metastatic", 3 screenings (0.5 %) were "metastatic" and 81 screenings (12.7 %) were "suspect". Out of this 81 suspect screening, only 47 screening have been checked, using 61 further investigations. No breast cancer metastasis was finally identified.
Conclusion:
Low rate of metastasis suggest reassessing metastasis screening before adjuvant chemotherapy for patients without lymph node involvement.
