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Evaluation of adipocytokines in children with chronic kidney disease

Maria Szczepańska1, Edyta Machura, Piotr Adamczyk

  • 1Chair and Department of Paediatrics, Zabrze, Medical University of Silesia, School of Medicine with the Division of Dentistry, Poland. dializy_dzieciece_zabrze@poczta.onet.pl.

Endokrynologia Polska
|May 2, 2015
PubMed

Insights

Serum adipocytokine levels are altered in children with chronic kidney disease (CKD). These changes may indicate cardiovascular risks and outcomes, highlighting the role of adipocytokines in pediatric kidney dysfunction.

Area of Science:

  • Endocrinology
  • Nephrology
  • Metabolic research

Background:

  • Adipose tissue functions as a metabolic and endocrine organ through secreted adipocytokines.
  • Adipocytokine levels in children with chronic kidney disease (CKD) may predict cardiovascular complications and long-term outcomes.
  • Evaluating adipocytokines can offer insights into the progression of CKD and post-transplant health.

Purpose of the Study:

  • To simultaneously measure serum concentrations of six adipocytokines in children with CKD.
  • To compare adipocytokine levels in children with CKD undergoing dialysis against a control group.
  • To investigate the relationship between specific adipocytokines and kidney dysfunction.

Main Methods:

  • Serum concentrations of adiponectin, apelin, chemerin, omentin, resistin, and vaspin were measured.
  • The study included 28 children with CKD stage 5 on hemodialysis or peritoneal dialysis.
  • Statistical analysis was performed, including adjustments for body mass index (BMI) and body surface area (BSA).

Main Results:

  • Children with CKD showed significantly higher levels of apelin, omentin, and resistin, and lower levels of vaspin, adiponectin, and chemerin compared to controls.
  • These differences persisted after adjusting for BMI.
  • Adjusting for BSA revealed no significant difference in vaspin, adiponectin, and chemerin levels between groups.
  • Correlations indicated negative relationships between omentin-apelin and omentin-vaspin, and positive relationships between adiponectin-chemerin and adiponectin-resistin.

Conclusions:

  • Altered serum adipocytokine concentrations are linked to kidney dysfunction in pediatric CKD.
  • Further longitudinal studies in larger pediatric cohorts are needed.
  • Investigating the role of adipocytokines in CKD development and progression is crucial for understanding risk factors.
Abstract

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