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Pentameric Ligand-gated Ion Channels : Insights from Computation

Reza Salari1, Sruthi Murlidaran2, Grace Brannigan1

  • 1Center for Computational and Integrative Biology, Rutgers University, Camden, NJ ; Department of Physics, Rutgers University, Camden, NJ.

Molecular Simulation
|May 2, 2015
PubMed
Summary

Computational studies reveal mechanisms of pentameric ligand-gated ion channels (pLGICs). Insights into gating, ion selectivity, and modulation complement structural data, aiding drug discovery.

Keywords:
Cys-loop receptormolecular dynamics simulationneurotransmitter receptor

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