Curcumin modulates cellular AP-1, NF-kB, and HPV16 E6 proteins in oral cancer
Alok Mishra1, Rakesh Kumar2, Abhishek Tyagi3
1Institute of Cytology and Preventive Oncology (ICMR), I-7, Sector-39, Noida 201301, India ; Ambedkar Centre for Biomedical Research (ACBR), University of Delhi, Delhi 110 007, India ; National Cancer Institute, NIH, Bethesda, MD, USA 20892.
Abstract:
In this study, we investigated the effects of the natural antioxidant curcumin on the HPV16-positive oral carcinoma cell line 93VU147T and demonstrated that curcumin is not only a potent inhibitor for the activity of host nuclear transcription factors AP-1 and NF-kB but it also selectively suppresses transcription of the HPV16/E6 oncogene during the carcinogenic process in oral cancer cells. This study suggests a therapeutic potential of curcumin for high-risk human papilloma virus (HPV)-infected oral cancers.
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