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Invasive group B streptococcal infection in infants in Shenzhen, China

Jiaosheng Zhang1, Ruizhen Zhao2, Yimei Dong1

  • 1Department of Internal Medicine, Shenzhen Children's Hospital Shenzhen 518038, P. R. China.

International Journal of Clinical and Experimental Medicine
|May 2, 2015
PubMed

Insights

Group B Streptococcus (GBS) is a significant cause of invasive infections in infants under 90 days in Shenzhen, China. High resistance to erythromycin and clindamycin necessitates careful antibiotic selection for treatment.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Microbiology

Background:

  • Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in neonates and young infants.
  • Understanding the epidemiology and antimicrobial susceptibility of GBS is crucial for effective management and prevention strategies.

Purpose of the Study:

  • To investigate the distribution and antibiotic susceptibility patterns of Group B Streptococcus (GBS) in infants younger than 90 days in Shenzhen, China.
  • To assess the clinical outcomes of invasive GBS infections in this vulnerable population.

Main Methods:

  • A retrospective study analyzed laboratory data, clinical manifestations, treatment, and outcomes of infants (< 90 days) with invasive GBS infection over a 4-year period.
  • Isolates from infants with GBS or non-GBS invasive infections were analyzed for GBS detection rates and antimicrobial susceptibility.

Main Results:

  • GBS was detected in 11.9% of invasive infections in infants < 90 days, with sepsis and meningitis being the primary diagnoses.
  • While GBS isolates remained susceptible to penicillin and vancomycin, significant resistance was observed against erythromycin (42%), clindamycin (64%), and tetracycline (93%).
  • Meningitis cases had a higher mortality (6.3%) and sequelae rate (25%) compared to sepsis.

Conclusions:

  • Group B Streptococcus poses a significant threat to infants < 90 days in Shenzhen, associated with considerable mortality and neurological sequelae.
  • The high prevalence of GBS resistance to erythromycin and clindamycin highlights the need for updated treatment guidelines and surveillance.
Abstract

Keywords:
Group B streptococcusinfantsepsis

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