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Related Experiment Video

Updated: Apr 13, 2026

Induction and Analysis of Epithelial to Mesenchymal Transition
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Epithelial Mesenchymal Transition: a double-edged sword.

Guislaine Barriere1, Pietro Fici1, Giulia Gallerani1

  • 1Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Via Piero Maroncelli 40, 47014 Meldola, FC Italy.

Clinical and Translational Medicine
|May 2, 2015
PubMed
Summary
This summary is machine-generated.

Epithelial mesenchymal transition (EMT) is vital for development and healing but can drive cancer invasion and fibrosis when perverted. This review explores EMT's dual role in health and disease.

Keywords:
CancerEMTEmbryogenesisFibrosisWound healing

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Area of Science:

  • Cell Biology
  • Developmental Biology
  • Pathology

Background:

  • Epithelial mesenchymal transition (EMT) is a fundamental biological process.
  • Dysregulated EMT contributes to pathological conditions like cancer and fibrosis.
  • Understanding EMT's role is crucial for clinical applications.

Purpose of the Study:

  • To review the clinical significance of EMT.
  • To delineate EMT's role in both physiological and pathological contexts.
  • To highlight EMT's involvement in cancer invasion and fibrosis.

Main Methods:

  • Literature review of EMT.
  • Analysis of EMT in embryogenesis and wound healing.
  • Examination of EMT's role in cancer metastasis and renal fibrosis.

Main Results:

  • EMT is essential for normal embryologic development and wound repair.
  • Aberrant EMT signaling promotes cancer cell motility and invasion, leading to circulating tumor cells.
  • EMT is implicated in the pathogenesis of fibrotic diseases, including renal fibrosis.

Conclusions:

  • EMT is a critical mechanism with a dual role in human health.
  • Understanding EMT's perversion in disease is key to developing therapeutic strategies.
  • EMT's clinical significance spans from development to cancer and chronic fibrotic conditions.