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Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Multipotency and Niche of Bulge Stem Cell01:06

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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Regulation of Hematopoietic Stem Cells01:01

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Related Experiment Video

Updated: Apr 13, 2026

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
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Looking for the elusive lung stem cell niche.

Ena Ray Banerjee1

  • 1Department of Zoology, Immunology and Regenerative Medicine Research Laboratory, University of Calcutta, 35, Ballygunge Circular Road, Kolkata, 700019 West Bengal India.

Translational Respiratory Medicine
|May 2, 2015
PubMed
Summary

This study explores stem cell biology for regenerative medicine, focusing on lung repair. Researchers identified functional lung stem cells and their niches, offering insights into counteracting lung degeneration and fibrosis.

Keywords:
BrdU pulse chase assayLung progenitorsLung stem cell nicheSide population cellsStem cells

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Area of Science:

  • Stem Cell Biology
  • Regenerative Medicine
  • Lung Biology

Background:

  • The lung is vulnerable to environmental damage, oxidative stress, and detoxification demands.
  • Degenerative lung diseases cause irreversible remodeling, posing therapeutic challenges.
  • Studying lung development and regeneration is crucial for addressing these issues.

Purpose of the Study:

  • To review stem cell types, actions, and models in invertebrates and higher organisms.
  • To present a novel approach for studying stem cell destruction patterns in lung injury models.
  • To identify and characterize lung stem cells and their niches in counteracting degeneration.

Main Methods:

  • Review of stem cell biology across different organisms.
  • Development of assays to evaluate stem cell and niche identity.
  • Utilizing an injury model to track stem cell destruction patterns.
  • Identification and characterization of functional lung stem cells.

Main Results:

  • Stem cells exhibit primitive characteristics and stimulus-specific behaviors.
  • Lung fibrosis involves progressive alveolar epithelium degeneration.
  • Functional lung stem cells and their niches were identified.
  • Assays tracking side population and label-retaining cells provided insights into lung degeneration.

Conclusions:

  • Understanding stem cell niches is key to counteracting lung degenerative processes.
  • This research provides a foundation for regenerative medicine approaches to lung disease.
  • The study highlights the importance of stem cell dynamics in lung repair and homeostasis.