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[Acute myelogenous leukemia developing in pregnancy with complete remission--a case report]
[Rinsho Ketsueki] the Japanese Journal of Clinical Hematology
|October 1, 1989
Summary
This case study details a pregnant woman with acute myelogenous leukemia who delivered a healthy infant. Successful chemotherapy achieved remission, and the child remained hematologically normal, with no evidence of placental transmission.
Area of Science:
- Hematology
- Oncology
- Obstetrics
Background:
- Acute myelogenous leukemia (AML) during pregnancy is rare.
- Management requires balancing maternal treatment with fetal well-being.
Observation:
- A 27-year-old pregnant woman presented with symptoms of AML at 38 weeks gestation.
- She received transfusions and delivered a healthy infant via normal labor.
- Postpartum chemotherapy (BHAC-MMP, DNR) induced complete remission.
Findings:
- The infant showed no hematological abnormalities.
- Placental examination revealed no leukemic cell invasion.
- Placental cord blood contained 9% blast cells.
Implications:
- This case suggests that successful treatment of maternal AML is possible during pregnancy.
- It highlights the importance of monitoring placental and cord blood for leukemic cells.
- Further research is needed on the potential for placental transmission of leukemia.