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Author Spotlight: Optimizing CFPS Systems for Synthetic Cell Construction
Published on: April 19, 2024
Protein synthesis in artificial cells: using compartmentalisation for spatial organisation in vesicle bioreactors
Yuval Elani1, Robert V Law, Oscar Ces
1Department of Chemistry, Imperial College London, Exhibition Road, SW7 2AZ, UK. o.ces@imperial.ac.uk.
None:
Whereas spatial organisation of function is ubiquitous in biology, it has been lacking in artificial cells. We rectify this by using multi-compartment vesicles as chassis for artificial cells, allowing distinct biological processes to be isolated in space. This is demonstrated by in vitro synthesis of two proteins in predefined vesicle regions.
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